منابع مشابه
Lower motor neuron degeneration in ALS
Running Title: Subgroups of ALS Baumann, F.1,2, Henderson, R.D.12, Ridall, P.G.34, Pettitt, A.N.4, Pamela A. McCombe1,2 1 Department of Neurology, Royal Brisbane & Women's Hospital, Queensland, Australia 2 University of Queensland Centre for Clinical Research, University of Queensland, Australia 3Department of Mathematics and Statistics, University of Lancaster, UK 4Discipline of Mathematical S...
متن کاملALS and other motor neuron diseases.
PURPOSE OF REVIEW This review describes the most common motor neuron disease, ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its pathophysiology, including new genetic underpinnings of the disease. This article also covers other motor neuron diseases, reviews how to distinguish them from ALS, and discusses their pathophysiology. RECENT FINDINGS In this ...
متن کاملRole of Mitochondrial Dysfunction in Motor Neuron Degeneration in ALS
Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. Progressive motor neuron loss causes muscle weakness, spasticity and fasciculation, eventually paralysis and finally death...
متن کاملUnraveling the mechanisms involved in motor neuron degeneration in ALS.
Although Charcot described amyotrophic lateral sclerosis (ALS) more than 130 years ago, the mechanism underlying the characteristic selective degeneration and death of motor neurons in this common adult motor neuron disease has remained a mystery. There is no effective remedy for this progressive, fatal disorder. Modern genetics has now identified mutations in one gene [Cu/Zn superoxide dismuta...
متن کاملMotor Neuron Death in ALS: Programmed by Astrocytes?
Motor neurons in ALS die via cell-autonomous and non-cell-autonomous mechanisms. Using adult human astrocytes and motor neurons, Re et al. (2014), in this issue of Neuron, discover that familial and sporadic ALS-derived human adult astrocytes secrete neurotoxic factors that selectively kill motor neurons through necroptosis, suggesting a new therapeutic avenue.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2006
ISSN: 1097-6256
DOI: 10.1038/nn0306-304